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  1. #1
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    Default Meth and SSRI's (antidepressants)

    Hi there swim just wanted to post this quick warning, please don't do methamphetamine or mdma if swiu also take an SSRI (selective serotonin reuptake inhibitor, commonly known as prozac, cipramil etc).

    This is incredibly dangerous and can cause a condition called serotonin syndrome in which the body is basically being poisoned from the feel good chemicals. Swim almost died from this and was the most painful stressful experience swim has ever had, period.

    Swim thought it was only the meth that caused it, but in fact had a yellow lady a couple of months later (yes not a very smart idea admittedly). About twenty minutes after dropping it swim collapsed and started vomiting and had to be resuscitated after a very quick drive to the hospital. Swim woke up in the most pain swim had ever been in and with every heartbeat swim felt as if they were getting punched in the head. Swim got given an anti-vomiting agent and was then filled to the brim with morphine to calm swims heart down which was going at a rate of 240bpm.

    Swim had quite happily combined the two drugs (ssri and meth) for some time and the resulting toxic reaction came as quite a surprise and a shock.

    Swim stopped all ssri treatment by tapering off 1/8th of swims dose weekly (5mg) over a two month period (swim didn't feel they were working very well anyway) and about a year later gave meth another go through oral ingestion (two days ago) and was fine although a little bit nervous about whether swim would be ok.

    Swim hasn't re-tried an E for the sheer lack of good quality product around. Swim has a friend who has been looking for some time for a pill that doesn't feel like its full of that horrid shit they call a recreational drug, (I mean wtf?!>) BZP but to no avail.

    Swim doesn't recommend ssri's for obvious reasons but feels it is possible they may be theraputic for the right person.

    Thank you very much for your attention and be safe and happy these holidays!

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  3. #2
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    are maoi's and ssri's similar? one quote that is plastered around the internet about mdma+maoi is as follows

    ...And finally, do not combine E with monoamine oxidase inhibitor drugs. Monoamine oxidase is the enzyme that helps to eventually slow down the effects of MDMA, without it, your body is a speeding car without any brakes--it has no way of controlling itself...
    Politics is the art of controlling your environment - HST

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  5. #3
    PANDY is offline Highly Valued TripMe Senior Contributor
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    Maoi's and SSRI's are different, here's my very basic understanding (which is open to correction)

    MAOI = MonoAmine Oxidase Inhibiter.

    SSRI = Selective Serotonin Re-uptake Inhibiter.


    But both work on managing/balancing the levels of important brain chems like - serotonin.
    E works to artificially increase the levels of serotonin in the brain.

    E+MAOI = E tricks the brain into releasing huge volumes of serotonin into the body and CNS. The natural MAO which would normally be working to eliminate the E has been suppressed by the MAO Inhibiter and so there is no mechanism to control the actions of the E which is to flood the CNS with serotonin, which feels great, but once it is overloaded serotonin syndrome is the result.

    E+SSRI = E tricks the brain into releasing huge volumes of serotonin into the body and CNS. SSRI's also trick the brain into releasing serotonin, keeping serotonin levels in the brain low. So a dual action occurs with the release of serotonin but the SSRI then blocks the serotonin from being recyled, reobsorbed back into the brain so it stays in the body and CNS which once overloaded serotonin syndrome is the result.
    Last edited by PANDY; 21-12-2008 at 11:32 PM.
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    Monoamine oxidase inhibitors (MAOIs) are a class of powerful antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating atypical depression, and have also shown efficacy in smoking cessation.
    Due to potentially lethal dietary and drug interactions, MAOIs had been reserved as a last line of defense, used only when other classes of antidepressant drugs (for example selective serotonin reuptake inhibitors and tricyclic antidepressants) have been tried unsuccessfully. Recently, however, a patch form of the drug selegiline, called Emsam, was developed. It was approved for use by the FDA on February 28, 2006.[1] When applied transdermally the drug does not enter the gastro-intestinal system as it does when taken orally, thereby decreasing the dangers of dietary interactions associated with MAOI pills.
    Source: http://en.wikipedia.org/wiki/MAO_inhibitor
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  7. #5
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    nice post...not so great about the hospital visit etc...but full credit for sharing the experience and warning others!!!!
    This type of information is invaluable!!!!

    +1 Karma

    ps.where the fucks the karma gone????

    peace.

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  9. #6
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    Default did it come out of nowhere?

    wow scarey stuff. i've been on mirtazapine(ssri) for years. i munch mdma,methylone and mephedrone regulaly. had heard of the syndrome but figured i was immune from it. got kinda nervous when started on meph.came of ssri(fortunatley found this v easy) pure glad i did. that sounds so feking aweful, so chuffed you pulled through. take care ,our hobby sure aint risk free. i honestly think the chems help me more than the ssri's every did.

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    ive mixed them many many times and also other drugs thrown in and have not had any problems

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    Swims not saying it happens to everyone, but wanted to warn that it can.

    Swim had previously combined many times before with no problems.

    The hospital staff said to swim that they hadn't seen anyone displaying that combination of symptoms before, so perhaps it is rare but possible nonetheless.

    Also thanks for the positive comments people swim hasn't logged in for awhile so hasn't replied sooner.
    Last edited by red_sparkle; 09-05-2009 at 03:36 PM.

  12. #9
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    Default METH and MDMA are safe with SSRI!

    Hey guys good to hear people are trying to be safe but meth and SSRI is perfectly safe, SWIM has used this combination dozens of times.

    In terms of MDMA causing serotonin syndrome when on SSRI: it doesn't. MDMA I hate to say doesn't work well on SSRIs because they block its mechanism of action. Yes both drugs are supposed to increase the amount of free serotonin in the brain but they work in very different ways. SSRI blocks the reuptake transporter so more serotonin remains available to receptors. MDMA's mode of action is the reversal of the reuptake transporter, it reverses the flow so the transporter actually releases serotonin rather than removing it from the synapse. Because SSRIs block the reuptake transporter they render MDMA useless. Anyone on an SSRI will agree that good ecstasy does nothing special while on an SSRI.
    I'm less sure about the mechanism of meth but i believe it is very similar. Most of its effect is on dopamine so will not be affected by SSRIs but it does also cause a smaller release of serotonin. From SWIM's personal experience with the combination SWIM's guess would be that SSRI blocks the serotonin side of this effect, but since meth is all about dopamine this is no tragedy.

    If you want to stay safe on MDMA I recommend keeping cool and making sure you have plenty of antioxidants in your system as to prevent serious neurotoxicity. Your brain produces important enzymes which can prevent MDMA neurotoxicity but only within a normal temperature range, if these enzymes stop working antioxidants can do the same job. Probably also a good idea with methamphetamine
    Peace!

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  14. #10
    Mister is offline Highly Valued TripMe Senior Contributor
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    Synthetic Cannabis
    ^ Holy shit haha.. SSRI's take processing priority in the brain meaning certain certain chemicals can build up to dangerous levels, theres no gain all you do is run a higher risk of recieving the negative effects. Scary advice.

    The part about MDxx is right though. If your unsure with MOA(I)/SSRI + Drug combinitations in any way at all, just don't do it.
    Last edited by Mister; 13-10-2011 at 08:25 AM.

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